Two teenage couples traveling across the backwoods of Texas searching for urban legends of serial killers end up as prisoners of a bizarre and sadistic backwater family of serial killers.

The sequel to House of 1000 Corpses – the Firefly family are ambushed at their isolated home by Sheriff Wydell and a squad of armed men guns blazing – yet only Otis and his sister, Baby, manage to escape the barrage of bullets unharmed. Hiding out in a backwater motel, the wanted siblings wait to rendezvous with their errant father, Captain Spaulding, killing whoever happens to stand in their way.